Publications

Pre-Prints

Marshall J, Xu J, Yeh N-H, Yun S, Nomura T, Armstrong J, Parker J, Contractor A. Modulation of the spatiotemporal dynamics of striatal direct pathway neurons and motor output by mGluR5. bioRxiv. 2023:2023.12.20.572676. doi: 10.1101/2023.12.20.572676.

Accepted Articles

Yun S & Parker JG. Cellular-resolution and bulk-fluorescence recordings of calcium activity yield reciprocal readouts of in vivo drug efficacy. Synapse. 2024;79(2):e70011. PubMed PMID: 40013455.

Lorch CM, Hayes NW, Xia JL, Fleps SW, McMorrow HE, Province HS, Frydman JA, Parker JG, Beutler LR. Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake. Cell reports. 2024;43(2):113675. doi: 10.1016/j.celrep.2024.113675. PubMed PMID: 38224492.

Borkar CD, Stelly CE, Fu X, Dorofeikova M, Le QE, Vutukuri R, Vo C, Walker A, Basavanhalli S, Duong A, Bean E, Resendez A, Parker JG, Tasker JG, Fadok JP. Top-down control of flight by a non-canonical cortico-amygdala pathway. Nature. 2024;625(7996):743-9. Epub 20240117. doi: 10.1038/s41586-023-06912-w. PubMed PMID: 38233522.

Yun S, Yang B, Anair JD, Martin MM, Fleps SW, Pamukcu A, Yeh NH, Contractor A, Kennedy A, Parker JG. Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons. Nat Neurosci. 2023;26(8):1417-28. Epub 20230713. doi: 10.1038/s41593-023-01390-9. PubMed PMID: 37443282; PMCID: PMC10842629.

Moya NA, Yun S, Fleps SW, Martin MM, Nadel JA, Beutler LR, Zweifel LS, Parker JG. The effect of selective nigrostriatal dopamine excess on behaviors linked to the cognitive and negative symptoms of schizophrenia. Neuropsychopharmacology. 2023;48(4):690-9. Epub 20221115. doi: 10.1038/s41386-022-01492-1. PubMed PMID: 36380221; PMCID: PMC9938164.

Legaria AA, Matikainen-Ankney BA, Yang B, Ahanonu B, Licholai JA, Parker JG, Kravitz AV. Fiber photometry in striatum reflects primarily nonsomatic changes in calcium. Nat Neurosci. 2022;25(9):1124-8. Epub 20220830. doi: 10.1038/s41593-022-01152-z. PubMed PMID: 36042311; PMCID: PMC10152879.

Trevathan JK, Asp AJ, Nicolai EN, Trevathan J, Kremer NA, Kozai TDY, Cheng D, Schachter M, Nassi JJ, Otte SL, Parker JG, Lujan JL, Ludwig K. Calcium imaging in freely-moving mice during electrical stimulation of deep brain structures. Journal of neural engineering. 2020. Epub 20200911. doi: 10.1088/1741-2552/abb7a4. PubMed PMID: 32916665; PMCID: PMC8485730.

Parker JG, Marshall JD, Ahanonu B, Wu YW, Kim TH, Grewe BF, Zhang Y, Li JZ, Ding JB, Ehlers MD, Schnitzer MJ. Diametric neural ensemble dynamics in parkinsonian and dyskinetic states. Nature. 2018;557(7704):177-82. Epub 20180502. doi: 10.1038/s41586-018-0090-6. PubMed PMID: 29720658; PMCID: PMC6526726.

Grewe BF, Gründemann J, Kitch LJ, Lecoq JA, Parker JG, Marshall JD, Larkin MC, Jercog PE, Grenier F, Li JZ, Lüthi A, Schnitzer MJ. Neural ensemble dynamics underlying a long-term associative memory. Nature. 2017;543(7647):670-5. Epub 20170322. doi: 10.1038/nature21682. PubMed PMID: 28329757; PMCID: PMC5378308.

Hamel EJ, Grewe BF, Parker JG, Schnitzer MJ. Cellular level brain imaging in behaving mammals: an engineering approach. Neuron. 2015;86(1):140-59. doi: 10.1016/j.neuron.2015.03.055. PubMed PMID: 25856491; PMCID: PMC5758309.

Güler AD, Rainwater A, Parker JG, Jones GL, Argilli E, Arenkiel BR, Ehlers MD, Bonci A, Zweifel LS, Palmiter RD. Transient activation of specific neurons in mice by selective expression of the capsaicin receptor. Nature communications. 2012;3:746. Epub 20120320. doi: 10.1038/ncomms1749. PubMed PMID: 22434189; PMCID: PMC3592340.

Wall VZ, Parker JG, Fadok JP, Darvas M, Zweifel L, Palmiter RD. A behavioral genetics approach to understanding D1 receptor involvement in phasic dopamine signaling. Mol Cell Neurosci. 2011;46(1):21-31. Epub 20101001. doi: 10.1016/j.mcn.2010.09.011. PubMed PMID: 20888914; PMCID: PMC3035386.

Parker JG, Wanat MJ, Soden ME, Ahmad K, Zweifel LS, Bamford NS, Palmiter RD. Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice. J Neurosci. 2011;31(47):17103-12. doi: 10.1523/jneurosci.1715-11.2011. PubMed PMID: 22114279; PMCID: PMC3235504.

Parker JG, Beutler LR, Palmiter RD. The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning. J Neurosci. 2011;31(31):11362-9. doi: 10.1523/jneurosci.2411-11.2011. PubMed PMID: 21813695; PMCID: PMC3156031.

Parker JG, Zweifel LS, Clark JJ, Evans SB, Phillips PE, Palmiter RD. Absence of NMDA receptors in dopamine neurons attenuates dopamine release but not conditioned approach during Pavlovian conditioning. Proc Natl Acad Sci U S A. 2010;107(30):13491-6. Epub 20100707. doi: 10.1073/pnas.1007827107. PubMed PMID: 20616081; PMCID: PMC2922155.

Clark JJ, Sandberg SG, Wanat MJ, Gan JO, Horne EA, Hart AS, Akers CA, Parker JG, Willuhn I, Martinez V, Evans SB, Stella N, Phillips PE. Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals. Nat Methods. 2010;7(2):126-9. Epub 20091227. doi: 10.1038/nmeth.1412. PubMed PMID: 20037591; PMCID: PMC2849934.

Zweifel LS, Parker JG, Lobb CJ, Rainwater A, Wall VZ, Fadok JP, Darvas M, Kim MJ, Mizumori SJ, Paladini CA, Phillips PE, Palmiter RD. Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior. Proc Natl Acad Sci U S A. 2009;106(18):7281-8. Epub 20090402. doi: 10.1073/pnas.0813415106. PubMed PMID: 19342487; PMCID: PMC2678650.